![]() 3 However, among patients over age 50, only 40% were noncancerous. 2-5 Results from one study of 628 patients who underwent nodal biopsy for peripheral lymphadenopathy revealed approximately 80% of nodes in patients under age 30 were noncancerous and likely had an infectious cause. A patient’s age is a significant factor in the evaluation of peripheral lymphadenopathy. Lymph nodes >1 cm in adults are considered abnormal and the differential diagnosis is broad ( TABLE 2-5). Generalized lymphadenopathy involves lymph node enlargement in more than one region of the body. A bone marrow biopsy confirmed follicular lymphoma grade II, Ann Arbor stage III. We consulted Oncology and they recommended a positron emission tomography (PET)/CT scan, which showed widespread lymphadenopathy. ![]() (Hodgkin’s and non-Hodgkin’s lymphoma (NHL) are uncommon causes of inguinal lymphadenopathy. An open biopsy of the largest inguinal lymph node revealed follicular lymphoma, a form of non-Hodgkin’s lymphoma. An abdominal and pelvic computed tomography (CT) scan with contrast identified nonspecific mesenteric, inguinal, retrocrural, and retroperitoneal adenopathy. All tests were normal, except the ultrasound, which revealed 3 solid left inguinal lymph nodes measuring 1.2 to 1.6 cm and 6 solid right inguinal lymph nodes measuring 1.1 to 1.8 cm. The patient’s work-up included a Pap smear, complete blood count (CBC), comprehensive metabolic panel (CMP), and pelvic and inguinal ultrasound. No additional lymphadenopathy or splenomegaly was found. The nodes were freely moveable and non-tender. Her vital signs and physical exam were normal with the exception of 3 enlarged left inguinal lymph nodes and approximately 5 enlarged right inguinal lymph nodes. She had a history of hyperlipidemia and surgical removal of a cutaneous melanoma at age 12. She denied fever, weight loss, abdominal pain, medication use, or recent foreign travel. The only complaints she had were fatigue, which she attributed to a work day that began at 4 am, and hot flashes. 2013 19:4850-4860.Ī 52-year-old woman presented to our family clinic for a well woman exam. New ultrasound techniques for lymph node evaluation. Sister Mary Joseph nodule-A case report with review of literature. Application of a prediction rule to select which patients presenting with lymphadenopathy should undergo a lymph node biopsy. Rapid access multidisciplinary lymph node diagnostic clinic: analysis of 550 patients. Chau I, Kelleher MT, Cunningham D, et al. ![]() An evaluation of the probability of malignant causes and the effectiveness of physicians’ workup. Unexplained lymphadenopathy in family practice. Why does my patient have lymphadenopathy or splenomegaly? Hematol Oncol Clin North Am. Lymphadenopathy: differential diagnosis and evaluation. Lymph node biopsy for diagnosis: a statistical study. Fine needle aspiration and core needle biopsy in the diagnosis of lymphadenopathy of unknown aetiology. Metzgeroth G, Schneider S, Walz C, et al.
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